The cotton seed cake is the residue left after the extraction of cotton seed oil from the seeds. This residue is also very useful from many aspects, for producing biofertilizer it is used as an essential raw material. Now-a-days bio-fertilizers are capturing the field of chemical fertilizers due to cheap availability, low cost & no side effect on land. So the use of cotton seed cake is also increasing in bio-fertilizer industries. This is a premium, natural, slow-release fertilizer that can be used alone or with other natural fertilizers.